Fundamental problems in developmental biology, such as the generation of asymmetry, differential transcription, and the execution of positional information, are all exhibited by a prokaryotic system, the Caulobacter cell cycle. Progeny cells resulting from each cell division have different developmental programs with respect to patterns of transcription and the initiation of DNA replication. The binary fission that yields dissimilar progeny results from asymmetry generated in the parent cell. An aspect of this fundamental developmental event is the temporally‐controlled biogenesis of a (...) polar flagellum. Several flagellar promoters require the histone‐like protein, integration host factor (IHF) for transcription activation. IHF introduces bends in DNA resulting in the reorganization of the higher‐order structure of the promoter region. These promoters appear to be transcribed from the chromosome in the swarmer pole of the predivisional cell. The newly replicated chromosomes in the predivisional cell differ in sedimentation coefficient and in the ability to initiate replication in the progeny cell. We hypothesize that the differential higher order structure of the two chromosomes contributes to both replication potential and transcription specificity. (shrink)

An early step in sporulation of the bacterium Bacillus subtilis, is the formation of two compartments in the developing sporangium: the mother cell and the forespore. These compartments differ in their programs of gene expression and developmental fate. The establishment of cell type within this simple developmental program, is accomplished by the compartmentalization of sigma subunits of RNA polymerase. The localization of these sigma factors results in compartment‐specific gene expression. Recent experiments have elucidated some of the early steps in the (...) establishment of 3V cell type. After septum formation, the activity of the sigma factor, σF, is confined to the forespore compartment. This, in turn, results in the localized expression of another developmental sigma factor, σG. The forespore localization of these two sigma factors, establishes the forespore line of gene expression. σF and σG also regulate mother cell events. σF activity in the forespore regulates the proteolytic processing of σE within the mother cell compartment. The localization σE activity leads to mother cell expression of another sigma factor, pro‐σK The proteolytic processing of pro‐σK to mature σK is controlled by the forespore sigma factor, σG Mature σK then directs the transcription of mother cell specific genes. Therefore, the initial localization of σF activity to the forespore compartment, orchestrates the establishment of cell type in both forespore and mother cell compartments. (shrink)

The Farm Animal Welfare Council’s concept of a Good Life gives an idea of an animal’s quality of life that is over and above that of a mere life worth living. The concept needs explanation and clarification, in order to be meaningful, particularly for consumers who purchase farm animal produce. The concept could allow assurance schemes to apply the label to assessments of both the potential of each method of production, conceptualised in ways expected to enhance consumers’ engagement such as (...) ‘naturalness’ and ‘freedom’; and the concept of a life worth living as a safeguard threshold below which no animal’s actual welfare should fall, based on each animal’s overall affective states. This may provide a framework for development of the Good Life concept, within scientific and sociological fields, in order to allow reliable and influential use by assessors, consumers and retailers. (shrink)

Animals are usually considered to lack the status of autonomous agents. Nevertheless, they do appear to make ostensible choices. This article considers whether, and how, I should respect animals' choices. I propose a concept of volitionality which can be respected if, and insofar as, doing so is in the best interests of the animal. Applying that concept, I will argue that an animals' choices be respected when the relevant human decision maker's capacities to decide are potentially challenged or compromised. For (...) example, it will be best to respect the animals' choice when the human decision maker: lacks accurate knowledge of the animal's subjective experiences; does not know what will lead to desirable experiences or allow for the avoidance of undesirable ones; is biased; is less aware of the animal's specific situation; cannot appreciate all elements comprehensively, including considering any value to the animal being allowed to make and implement a choice, such as where a lack of control or liberty would be unpleasant or where an animal would usefully learn from the process of choice-making; and when the animal's choice is achievable. This additionally suggests that we may often beneficially choose to set up situations that empower animals to make better choices. (shrink)

This fully revised and extended edition of James Nickel's classic study explains and defends the conception of human rights found in the Universal Declaration of Human Rights and subsequent human rights treaties. Combining philosophical, legal, and political approaches, Nickel addresses questions about what human rights are, what their content should be, and whether and how they can be justified.

The United States has never been culturally or religiously homogeneous, but its diversity has greatly increased over the last century. Although the U.S. was first a multicultural nation through conquest and enslavement, its present diversity is due equally to immigration. In this paper I try to explain the difference it makes for one area of thought and policy – equal opportunity – if we incorporate cultural and religious pluralism into our national self-image. Formulating and implementing a policy of equal opportunity (...) is more difficult in diverse, pluralistic countries than it is in homogeneous ones. My focus is cultural and religious diversity in the United States, but my conclusions will apply to many other countries – including ones whose pluralism is found more in religion than in culture. (shrink)

The concept of hegemonic masculinity has influenced gender studies across many academic fields but has also attracted serious criticism. The authors trace the origin of the concept in a convergence of ideas in the early 1980s and map the ways it was applied when research on men and masculinities expanded. Evaluating the principal criticisms, the authors defend the underlying concept of masculinity, which in most research use is neither reified nor essentialist. However, the criticism of trait models of gender and (...) rigid typologies is sound. The treatment of the subject in research on hegemonic masculinity can be improved with the aid of recent psychological models, although limits to discursive flexibility must be recognized. The concept of hegemonic masculinity does not equate to a model of social reproduction; we need to recognize social struggles in which subordinated masculinities influence dominant forms. Finally, the authors review what has been confirmed from early formulations and what needs to be discarded. The authors suggest reformulation of the concept in four areas: a more complex model of gender hierarchy, emphasizing the agency of women; explicit recognition of the geography of masculinities, emphasizing the interplay among local, regional, and global levels; a more specific treatment of embodiment in contexts of privilege and power; and a stronger emphasis on the dynamics of hegemonic masculinity, recognizing internal contradictions and the possibilities of movement toward gender democracy. (shrink)

Profit is a concept that both causes and manifests deep conflict and division. It is not merely that people disagree over whether it is good or bad. The very meaning of the concept and its role in competing theories necessitates the deepest possible disagreement; people cannot agree on what profit is. Still, simply learning the starkly different sentiments expressed about profit gives us some feel for the depth of the conflict. Friends of capitalism have praised profit as central to the (...) achievement of prosperity and to civilized modern life. Calvin Coolidge, that silent sentinel of American business, said, “Profit and civilization go hand in hand.” F. A. Hayek tells us that in the evolution of the structure of human activities, profitability works as a signal that guides selection towards what makes man more fruitful; only what is more profitable will, as a rule, nourish more people, for it sacrifices less than it adds. (shrink)

It is nearly 10 years since Patrick Haggard and colleagues first reported the ‘intentional binding’ effect . The intentional binding effect refers to the subjective compression of the temporal interval between a voluntary action and its external sensory consequence. Since the first report, considerable interest has been generated and a fascinating array of studies has accumulated. Much of the interest in intentional binding comes from the promise to shed light on human agency. In this review we survey studies on intentional (...) binding, focusing, in particular, on the link between intentional binding and the sense of agency . We suggest that, whilst it is yet to be fully explicated, the link between intentional binding and the sense of agency is compelling. We conclude by considering outstanding questions and future directions for research on intentional binding. (shrink)

What do the rules of logic say about the meanings of the symbols they govern? In this book, James W. Garson examines the inferential behaviour of logical connectives, whose behaviour is defined by strict rules, and proves definitive results concerning exactly what those rules express about connective truth conditions. He explores the ways in which, depending on circumstances, a system of rules may provide no interpretation of a connective at all, or the interpretation we ordinarily expect for it, or (...) an unfamiliar or novel interpretation. He also shows how the novel interpretations thus generated may be used to help analyse philosophical problems such as vagueness and the open future. His book will be valuable for graduates and specialists in logic, philosophy of logic, and philosophy of language. (shrink)

The experience of causation is a pervasive product of the human mind. Moreover, the experience of causing an event alters subjective time: actions are perceived as temporally shifted towards their effects [Haggard, P., Clark, S., & Kalogeras, J.. Voluntary action and conscious awareness. Nature Neuroscience, 5, 382-385]. This temporal shift depends partly on advance prediction of the effects of action, and partly on inferential "postdictive" explanations of sensory effects of action. We investigated whether a single factor of statistical contingency could (...) explain both these aspects of causal experience. We studied the time at which people perceived a simple manual action to occur, when statistical contingency indicated a causal relation between action and effect, and when no such relation was indicated. Both predictive and inferential "postdictive" shifts in the time of action depended on strong contingency between action and effect. The experience of agency involves a process of causal learning based on statistical contingency. (shrink)

Behavior genetics is a controversial science. For decades, scholars have sought to understand the role of heredity in human behavior and life-course outcomes. Recently, technological advances and the rapid expansion of genomic databases have facilitated the discovery of genes associated with human phenotypes such as educational attainment and substance use disorders. To maximize the potential of this flourishing science, and to minimize potential harms, careful analysis of what it would mean for genes to be causes of human behavior is needed. (...) In this paper, we advance a framework for identifying instances of genetic causes, interpreting those causal relationships, and applying them to advance causal knowledge more generally in the social sciences. Central to thinking about genes as causes is counterfactual reasoning, the cornerstone of causal thinking in statistics, medicine, and philosophy. We argue that within-family genetic effects represent the product of a counterfactual comparison in the same way as average treatment effects (ATEs) from randomized controlled trials (RCTs). Both ATEs from RCTs and within-family genetic effects are shallow causes: They operate within intricate causal systems (non-unitary), produce heterogeneous effects across individuals (non-uniform), and are not mechanistically informative (non-explanatory). Despite these limitations, shallow causal knowledge can be used to improve understanding of the etiology of human behavior and to explore sources of heterogeneity and fade-out in treatment effects. (shrink)

Bogen and Woodward claim that the function of scientific theories is to account for 'phenomena', which they describe both as investigator-independent constituents of the world and as corresponding to patterns in data sets. I argue that, if phenomena are considered to correspond to patterns in data, it is inadmissible to regard them as investigator-independent entities. Bogen and Woodward's account of phenomena is thus incoherent. I offer an alternative account, according to which phenomena are investigator-relative entities. All the infinitely many patterns (...) that data sets exhibit have equal intrinsic claim to the status of phenomenon: each investigator may stipulate which patterns correspond to phenomena for him or her. My notion of phenomena accords better both with experimental practice and with the historical development of science. (shrink)

How reasonable and rational can science be when its practitioners speak of "revolutions" in their thinking and extol certain theories for their "beauty"? James W. McAllister addresses this question with the first systematic study of the aesthetic evaluations that scientists pass on their theories. P. A. M. Dirac explained why he embraced relativity by saying, "It is the essential beauty of the theory which I feel is the real reason for believing in it." Dirac's claim seems to belie rationalist (...) accounts of science. Using this and a wealth of other historical examples, McAllister explains how scientists' aesthetic preferences are influenced by the empirical track record of theories, describes the origin and development of aesthetic styles of theorizing, and reconsiders whether simplicity is an empirical or an aesthetic virtue of theories. McAllister then advances an innovative model of scientific revolutions, in opposition to that of Thomas S. Kuhn. Three detailed studies demonstrate the interconnection of empirical performance, beauty, and revolution. One examines the impact of new construction materials on the history of architecture. Another reexamines the transition from the Ptolemaic system to Kepler's theory in planetary astronomy, and the third documents the rise of relativity and quantum theory in the twentieth century. (shrink)

It is commonly asserted that “death is not a welfare issue” and this has been reflected in welfare legislation and policy in many countries. However, this creates a conflict for many who consider animal welfare to be an appropriate basis for decision-making in animal ethics but also consider that an animal’s death is ethically significant. To reconcile these viewpoints, this paper attempts to formulate an account of death as a welfare issue. Welfare issues are issues that refer to evaluations concerning (...) an animal’s interests. This includes evaluations that refer only to comparisons between the presence and absence of states, including positive states. This means that an animal’s death may be a welfare issue insofar as it leads to the exclusion of relevant positive states. This allows us to deny that death is necessarily not a welfare issue. (shrink)

Designed for use by philosophy students, this 2006 book provides an accessible, yet technically sound treatment of modal logic and its philosophical applications. Every effort has been made to simplify the presentation by using diagrams in place of more complex mathematical apparatus. These and other innovations provide philosophers with easy access to a rich variety of topics in modal logic, including a full coverage of quantified modal logic, non-rigid designators, definite descriptions, and the de-re de-dictio distinction. Discussion of philosophical issues (...) concerning the development of modal logic is woven into the text. The book uses natural deduction systems and also includes a diagram technique that extends the method of truth trees to modal logic. This feature provides a foundation for a novel method for showing completeness, one that is easy to extend to systems that include quantifiers. (shrink)

Designed for use by philosophy students, this book provides an accessible, yet technically sound treatment of modal logic and its philosophical applications. Every effort has been made to simplify the presentation by using diagrams in place of more complex mathematical apparatus. These and other innovations provide philosophers with easy access to a rich variety of topics in modal logic, including a full coverage of quantified modal logic, non-rigid designators, definite descriptions, and the de-re de-dictio distinction. Discussion of philosophical issues concerning (...) the development of modal logic is woven into the text. The book uses natural deduction systems and also includes a diagram technique that extends the method of truth trees to modal logic. This feature provides a foundation for a novel method for showing completeness, one that is easy to extend to systems that include quantifiers. (shrink)

At present, Third World countries owe over one trillion dollars to the developed Western nations; much of the debt is held by the leading international commercial banks. The debt of six Latin American countries alone — Argentina, Brazil, Chile, Mexico, Peru, and Venezuela — is over $330 billion, of which $240 billion is owed to commercial banks. Let us immediately narrow our focus to loans made by the major international commercial banks to Third World governments. We shall not be concerned (...) with government-to-government loans, or private-party-to-private-party loans, or with debt owed to the World Bank or the International Monetary Fund. The bank-to-government loans — the so-called “sovereign loans” — are the most economically troublesome and morally interesting. The largest lenders, at least with respect to the Latin American countries, are the American banks Citibank, Chase Manhattan, Bank of America, Manufacturers Hanover, and Chemical Bank. About fifteen Third World countries have serious debt problems, including the largest: Brazil, Mexico, and Argentina. (shrink)

This book on modal logic is especially designed for philosophy students. It provides an accessible yet technically sound treatment of modal logic and its philosophical applications. Every effort is made to simplify the presentation by using diagrams instead of more complex mathematical apparatus. These and other innovations provide philosophers with easy access to a rich variety of topics in modal logic, including a full coverage of quantified modal logic, non-rigid designators, definite descriptions, and the de-re de-dicto distinction. Discussion of philosophical (...) issues concerning the development of modal logic is woven into the text. The book uses natural deduction systems, which are widely regarded as the easiest to teach and use. It also includes a diagram technique that extends the method of truth trees to modal logic. This provides a foundation for a novel method for showing completeness that is easy to extend to quantifiers. This second edition contains a new chapter on logics of conditionals, an updated and expanded bibliography, and is updated throughout. (shrink)

Sense of agency refers to the sense of initiating and controlling actions in order to influence events in the outside world. Recently, a distinction between implicit and explicit aspects of sense of agency has been proposed, analogous to distinctions found in other areas of cognition, notably learning. However, there is yet no strong evidence supporting separable implicit and explicit components of sense of agency. The so-called ‘Perruchet paradigm’ offers one of the few convincing demonstrations of separable implicit and explicit learning (...) systems. We adopted this approach to evaluate the implicit–explicit distinction in the context of a simple task in which outcomes were probabilistically caused by actions. In line with our initial predictions, we found evidence of a dissociation. We discuss the implications of this result for theories of sense of agency. (shrink)

This article discusses the relation between features of empirical data and structures in the world. I defend the following claims. Any empirical data set exhibits all possible patterns, each with a certain noise term. The magnitude and other properties of this noise term are irrelevant to the evidential status of a pattern: all patterns exhibited in empirical data constitute evidence of structures in the world. Furthermore, distinct patterns constitute evidence of distinct structures in the world. It follows that the world (...) must be regarded as containing all possible structures. The remainder of the article is devoted to elucidating the meaning and implications of the latter claim. (shrink)

This paper assesses the effect of DNA barcoding—the use of informative genetic markers to identify and discriminate between species—on taxonomy. Throughout, we interpret this in terms of _varipraxis_, a concept we introduce to make sense of the treatment of biological variation by scientists and other practitioners. From its inception, DNA barcoding was criticised for being reductive, in attempting to replace multiple forms of taxonomic evidence with just one: DNA sequence variation in one or a few indicative genes. We show, though, (...) how DNA barcoding has not narrowed or reduced taxonomy in the way it was projected to. We examine the development and implementation of DNA barcoding across three kingdoms of life: animals, plants, and protists. Through this, we demonstrate that for DNA barcoding to work, the range of acceptable intra-specific variation needs to be demarcated from variation deemed to be characteristic of inter-specific differences. Consequently, biological processes responsible for particular patterns of variation need to be investigated and understood. This encourages an integrative disposition towards understanding and explaining the evolutionary processes affecting the rate and nature of change at the nucleotide level. We detail how the impact of DNA barcoding has manifested differently across the three kingdoms we examine, assessing this in terms of the ontological commitments that are held and instantiated in practice. Based on this evaluation, we consider the problem of studying multi-kingdom communities, and assess the consequences of our analysis for understanding classification and taxonomy. (shrink)

Most important, James W. Walters compares and contrasts Buber's and feminism's personalist ethics in light of two considerations: the lack of attention by ...

Several quantitative techniques for choosing among data models are available. Among these are techniques based on algorithmic information theory, minimum description length theory, and the Akaike information criterion. All these techniques are designed to identify a single model of a data set as being the closest to the truth. I argue, using examples, that many data sets in science show multiple patterns, providing evidence for multiple phenomena. For any such data set, there is more than one data model that must (...) be considered close to the truth. I conclude that, since the established techniques for choosing among data models are unequipped to handle these cases, they cannot be regarded as adequate. ‡I presented a previous version of this paper at the 20th Biennial Meeting of the Philosophy of Science Association, Vancouver, November 2006. I am grateful to the audience for constructive discussion. I thank Leiden University students Marjolein Eysink Smeets and Lenneke Schrier for suggesting the cortisol example, and Remko van der Geest for comments on a draft. †To contact the author, please write to: Faculty of Philosophy, University of Leiden, P.O. Box 9515, 2300 RA Leiden, The Netherlands; e-mail: [email protected]. (shrink)

Murray Gell-Mann has proposed the concept of effective complexity as a measure of information content. The effective complexity of a string of digits is defined as the algorithmic complexity of the regular component of the string. This paper argues that the effective complexity of a given string is not uniquely determined. The effective complexity of a string admitting a physical interpretation, such as an empirical data set, depends on the cognitive and practical interests of investigators. The effective complexity of a (...) string as a purely formal construct, lacking a physical interpretation, is either close to zero, or equal to the string's algorithmic complexity, or arbitrary, depending on the auxiliary criterion chosen to pick out the regular component of the string. Because of this flaw, the concept of effective complexity is unsuitable as a measure of information content. (shrink)

Journal of Religious Ethics, Volume 49, Issue 4, Page 768-792, December 2021.

Linkage arguments, which defend a controversial right by showing that it is indispensable or highly useful to an uncontroversial right, are sometimes used to defend the right to health care. This article evaluates such arguments when used to defend RHC. Three common errors in using linkage arguments are neglecting levels of implementation, expanding the scope of the supported right beyond its uncontroversial domain, and giving too much credit to the supporting right for outcomes in its area. A familiar linkage argument (...) for RHC focuses on its contributions to the right to life. Among the problems with this argument are that it requires a positive conception of the right to life that is not uncontroversial and that it only justifies the subset of RHC that seeks to prevent loss of life. A linkage argument for RHC with better prospects claims that a well-realized right to health care enhances the realization of a number of uncontroversial rights. (shrink)

Given the recent ethics scandals in the United States, there has been a renewed focus on understanding the antecedents to ethical decision-making in the research literature. Since ethical norms and standards of behavior are not universally consistent, an individual’s choice of referent may exert a large influence on his/her ethical decision-making. This study used a social identity theory lens to empirically examine the relative influence of the macro- and micro-level variables of national culture and peers on an individual’s intention to (...) behave ethically. Our sample consisted of respondents from Germany, Italy, and Japan. The results indicated that both national culture and peers were found to act as significant referents in ethical decision-making dilemmas. Although peers exerted a much stronger influence on an individual’s ethical decision-making, the impact of peers varied depending on the national culture levels of individualism and power distance. (shrink)

Recent research has shown that human instrumental action is associated with systematic changes in time perception: The interval between a voluntary action and an outcome is perceived as shorter than the interval between a physically similar involuntary movement and an outcome. The study by, Ebert and Wegner suggests that this change in time perception is related to higher order agency experience. Notwithstanding certain issues arising from their study, which are discussed, we believe it offers validation of binding as a measure (...) of sense of agency. (shrink)

From the 1980s onwards, the Roslin Institute and its predecessor organizations faced budget cuts, organizational upheaval and considerable insecurity. Over the next few decades, it was transformed by the introduction of molecular biology and transgenic research, but remained a hub of animal geneticists conducting research aimed at the livestock-breeding industry. This paper explores how these animal geneticists embraced genomics in response to the many-faceted precarity that the Roslin Institute faced, establishing it as a global centre for pig genomics research through (...) forging and leading the Pig Gene Mapping Project (PiGMaP); developing and hosting resources, such as a database for genetic linkage data; and producing associated statistical and software tools to analyse the data. The Roslin Institute leveraged these resources to play a key role in further international collaborations as a hedge against precarity. This adoption of genomics was strategically useful, as it took advantage of policy shifts at the national and European levels towards funding research with biotechnological potential. As genomics constitutes a set of infrastructures and resources with manifold uses, the development of capabilities in this domain also helped Roslin to diversify as a response to precarity. (shrink)

The central terms of certain theories which were valued highly in the past, such as the phlogiston theory, are now believed by realists not to refer. Laudan and others have claimed that, in the light of the existence of such theories, scientific realism is untenable. This paper argues in response that realism is consistent with — and indeed is able to explain — such theories' having been highly valued and yet not being close to the truth. It follows that the (...) set of highly-valued past theories cited by Laudan, presumed to militate against realism, is in fact innocuous to the doctrine. The argument hinges largely on identifying the grounds on which theory-adoption is actually performed. (shrink)

Preface to the fifth edition -- A world of difference -- A universe charged with the grandeur of God : Christian theism -- The clockwork universe : deism -- The silence of finite space : naturalism -- Zero point : nihilism -- Beyond nihilism : existentialism -- Journey to the east : eastern pantheistic monism -- A separate universe : the New Age spirituality without religion -- The vanished horizon : postmodernism -- A view from the Middle East : Islamic (...) theism -- The examined life. (shrink)

For many years there has been a debate about the role of the parietal lobe in the generation of behavior. Does it generate movement plans (intention) or choose objects in the environment for further processing? To answer this, we focus on the lateral intraparietal area (LIP), an area that has been shown to play independent roles in target selection for saccades and the generation of visual attention. Based on results from a variety of tasks, we propose that LIP acts as (...) a priority map in which objects are represented by activity proportional to their behavioral priority. We present evidence to show that the priority map combines bottom-up inputs like a rapid visual response with an array of top-down signals like a saccade plan. The spatial location representing the peak of the map is used by the oculomotor system to target saccades and by the visual system to guide visual attention. (shrink)